Allosteric drugs: thinking outside the active-site box

Thinking outside the box

Health care education is developing at a high pace, all around the world. New ideas are needed, new ideas that work and help us meet the goals we set for improving health care education. PME wants to contribute to seeing with new eyes by offering its readers articles that are inspirational by nature. Articles with new ideas or with research based on new ideas that work. This inspiration combine...

Dysphagia: Thinking outside the box

Dysphagia is a common symptom that is important to recognise and appropriately manage, given that causes include life threatening oesophageal neoplasia, oropharyngeal dysfunction, the risk of aspiration, as well as chronic disabling gastroesophageal reflux (GORD). The predominant causes of dysphagia varies between cohorts depending on the interplay between genetic predisposition and environment...

Thinking Outside of the Box

Advancements in the fields of traumatology and medicine are made based on sound research and scientific methodology. Today, those with novel ideas and innovations pave the path towards better patient healthcare. This in turn translates to lesser morbidity and mortality, shorter hospital stay and less lost work days for the patient. In order for scientists and clinicians to be creative they must...

Thinking outside the TATA box.

When I was doing my PhD research, in the middle of the last century, the nature and complexity of the RNA transcripts of the genome was a topic of lively debate, into which my own work became drawn. The complexity of the mRNA population in a given tissue, celltype or developmental stage—considered as transcripts that were polyadenylated and associated with ribosomes—was estimated to represent s...

The HRL Laboratories: Thinking Outside the Box